Many Pharmaceutical products are highly reactive and volatile hence it is of utmost important to produce them in Aseptic Conditions that will not contaminate the product. LITCO has mastered the best practices in Industry to provide the best sterile, secured and highly productive plant for Aseptic production. Automation is of utmost importance in Sterile Production and LITCO offers the best automotive process and instrumentation with almost no manual handling of the material.

LITCO’s standard Sterile Mfg. Plant consists of the following:

• Sterile Mixing Vessel ( Magentic / Mixing Anchor)
• Sterile Storage Vessel
• Powder Feeding System
• In-line Homogenizer
• Membrane Filter
• Cartridge Filter
• Vacuum System for Online Transfer
• Plant Pipeline
• Aseptic Valves
• Automated Control Panel

In our Sterile Manufacturing Plant, we can produce

• IV Fluid
• Sterile Solution
• Large/Small Volume Parenteral Drug
• Serum
• SVP Solution
• Vaccine
• Oncology

Working Principle Of Sterile Mfg. Plant

The Sterile Manufacturing Plant Manufacturer is designed to produce aseptic products hence sterility and automation is most important, to ensure minimal contact. According to requirement, the Sterile Mixing Vessels are placed with the provision for a powder feeding system. The Sterile Mixing Vessels are provided with an Anchor type Agitator for homogeneous mixing of the materials. The Anchor type Agitator can be a Mechanical/Magnetic Stirrer. The Magnetic Stirrer is most recommended to ensure least contamination and contact. The product is then passed through an In-line Homogenizer for further mixing. Then it is made to pass through a series of Filters such as the Membrane or Cartridge Filter depending upon the user’s requirement. The entire transfer is handled by an Online Vacuum Transfer system for the best productivity and ease of use.

Another important aspect in Sterile Mfg. Plants is to ensure no Dead Legs to prevent unwanted microbial growth. Hence Zero Dead Leg Valves with other Aseptic Valves are provided according to the plant design to prevent impurity formation. The produced Sterile solution is finally transferred to the Sterile Storage Vessel which is then carried forward for packaging or other processes. The entire process is undertaken by our smart Automated Control System with an easy-to-use HMI ensuring all the processes are completed on-time, efficiently and hassle-free with no manual handling.

At LITCO, we manufacture Sterile Manufacturing Plant as per our Customer’s requirements. We specialise in providing our Client’s customised Plant design and Turnkey solutions. Please drop in your requirements under our Contacts for further specifications and quotations.

Special Features:

• Complete aseptic design with Magnetic mixer & high shear Magnetic emulsifier.
• Zero dead leg aseptic design Flush bottom outlet diaphragm valve with SIP facility.
• Sampling valve zero dead leg type with CIP/SIP facility.
• Volume monitoring by Load Cell for accurate measurement and result.
• PH Sensor / Conductivity Sensor provided on demand for online check Product PH & Conductivity.
• The gaskets used are of Silicon (food grade) to avoid contamination
• Mechanical Seal is provided at the Stirrer Entry to prevent back-flow and contamination.
• All material transfers are done by vacuum hence assuring minimal contact.
• All the Vessels are CGMP standard (paint free construction).
• All contact parts are made of SS 316 grade and non-contact parts SS 304.
• All pipelines are joined with Tri-clover ended Joints assuring safe and smooth transport.
• PLC with HMI Touchscreen with CFR 21 Part 11 complied with SCADA for  full Automatic Control & Processing.